Is the 2010 Mercedes-Benz E 350 a bad year?
184 owner complaints to NHTSA. Engine and transmission complaints are in line with other E 350 years.
Keep it
Engine and transmission complaints for the 2010 Mercedes-Benz E 350 are in line with other E 350 years. Air bags stands out for this year: see below.
The verdict moves with mileage: the same car reads differently at 30,000 and at 150,000 miles.
What 2010 E 350 owners report, by mileage
Each system owners named in five or more complaints, with the mileage range where the middle half of those complaints were filed. Read at 50,000 miles.
| SYSTEM | COMPLAINTS | MIDDLE HALF FILED AT | TYPICAL US REPAIR BILLS |
|---|---|---|---|
| Air bagsSTANDS OUT | 68 (37%) | 30k–72k miles · around this mileage | — |
| Electrical system | 17 (9%) | 47k–90k miles · around this mileage | 12-volt battery replacement $100–$400 · Starter motor replacement $350–$1,200 |
| Engine | 15 (8%) | 48k–93k miles · around this mileage | Valve cover gasket replacement $110–$500 · Timing chain replacement $1,000–$4,000 |
| Fuel system | 20 (11%) | 56k–100k miles · ahead | Fuel pump replacement $220–$1,500 · Fuel injector replacement (one injector) $300–$1,200 |
| Suspension | 17 (9%) | too few with a mileage | — |
| Brakes | 14 (8%) | too few with a mileage | — |
| Transmission and drivetrain | 14 (8%) | too few with a mileage | — |
| Body structure | 11 (6%) | too few with a mileage | — |
| Steering | 8 (4%) | too few with a mileage | — |
| Exterior lighting | 5 (3%) | too few with a mileage | — |
Bills are typical US ranges from the sources named in the tool (J.D. Power, Kelley Blue Book, CarParts.com and others), printed only for systems that stand out or sit at or ahead of 50,000 miles. Not a quote.
What owners reported alongside their complaints
Of 184 complaints: 9 mention a crash · 5 report an injury · 3 say the car was towed.
6 complaints were filed in the last 12 months, the newest in Sep 2026.
Counts of what owners wrote in their complaints, not verified by anyone.
Recalls for the 2010 Mercedes-Benz E 350: 4
Various control units may have been updated with incorrect software configuration during a service repair. This can result in various system failures, such as loss of drive power, reduced exterior lighting, or loss of dynamic control functions, including stability and traction control. Various system failures, such as loss of drive power, reduced exterior lighting, or loss of dynamic control functions including stability and traction control, can increase the risk of a crash.
In the event of a crash necessitating deployment of the passenger frontal air bag, these passenger air bag inflator may explode due to propellant degradation occurring after long-term exposure to absolute humidity and temperature cycling. An inflator explosion may result in sharp metal fragments striking the driver or other occupants resulting in serious injury or death.
These vehicles are equipped with certain air bag inflators assembled as part of the passenger frontal air bag modules, and used as original equipment or replacement equipment. An inflator rupture may result in metal fragments striking the vehicle occupants resulting in serious injury or death.
Mercedes-Benz USA, LLC. Upon deployment of the driver's frontal air bag, excessive internal pressure may cause the inflator to rupture. In the event of a crash necessitating deployment of the driver's frontal air bag, the inflator could rupture with metal fragments striking the driver or other occupants resulting in serious injury or death.
A recall may cover only some cars of a model year; the campaign size counts every model and year it lists. Enter your VIN at nhtsa.gov/recalls: dealers fix open recalls free.
Service bulletins from Mercedes-Benz: 159
Repair instructions Mercedes-Benz sent its dealers for symptoms seen in the shop on the 2010 Mercedes-Benz E 350. Ask a dealer or mechanic for a bulletin by its number.
Single throttle lift-off clunking noise from the side shaft when moving off (audible at the outboard end)
Tension-releasing impact of the propeller shaft with the force-free in D "KID" function, after vehicle has stopped
Harsh engagement when changing gear range from P to D or R
Ticking or pulsing noise from high-pressure pump and/or fuel injectors
NHTSA defect investigations: 2
Desiccated Air Bag Inflator Rupture
Rear brake line failure
Neighbouring years
2009 E 350: 65 complaints, keep it · 2011 E 350: 223 complaints, keep it.
Every Mercedes-Benz E 350 year
2003 · 2004 · 2005 · 2006 · 2007 · 2008 · 2009 · 2010 · 2011 · 2012 · 2013 · 2014 · 2015 · 2016 · 2017 · 2020 · 2021 · 2022 · 2023 · 2024 · 2025 · 2026 · All E 350 years side by side
Other Mercedes-Benz models: Mercedes-Benz AMG E 55 · Mercedes-Benz C 230 · Mercedes-Benz C 250 · Mercedes-Benz C 300 · Mercedes-Benz C 320 · Mercedes-Benz C 350 · Mercedes-Benz CLA 250 · Mercedes-Benz E 300 · Mercedes-Benz E 320 · Mercedes-Benz E 500 · Mercedes-Benz E 550 · Mercedes-Benz GL 450 · Mercedes-Benz GLA 250 · Mercedes-Benz GLC 300 · Mercedes-Benz GLE 350 · Mercedes-Benz GLK 350 · Mercedes-Benz ML 320 · Mercedes-Benz ML 350 · Mercedes-Benz Metris · Mercedes-Benz R 350 · Mercedes-Benz S 430 · Mercedes-Benz S 500 · Mercedes-Benz S 550 · Mercedes-Benz S Class · Mercedes-Benz SL 500 · Mercedes-Benz Sprinter 2500 · Mercedes-Benz Sprinter 3500. All makes and models.
Questions
Is the 2010 Mercedes-Benz E 350 a bad year?
184 owner complaints to NHTSA. Engine and transmission complaints are in line with other E 350 years. At 50,000 miles the tool says: Keep it.
What are the most common problems with the 2010 Mercedes-Benz E 350?
By owner complaints to NHTSA: air bags (68), electrical system (17), engine (15), fuel system (20), suspension (17).
How many recalls does the 2010 Mercedes-Benz E 350 have?
4 recall campaigns list this model year: Exterior lighting (NHTSA 22V-168), Air bags (NHTSA 18V-043), Air bags (NHTSA 16V-363), Air bags (NHTSA 16V-081). A recall may cover only some cars; check by VIN at nhtsa.gov/recalls.
Method: counts of unverified owner complaints filed with NHTSA, compared only with other years of the same model (sales volumes are unknown, so no failure rate is computed). A system stands out at 40+ complaints and at least twice the model's quiet (lower-quartile) year, or twice the share across every vehicle of that model year. The mileage range is the 25th to 75th percentile of the mileages owners reported. Data received by NHTSA through November 5, 2026. Repair prices are typical US ranges from named sources, not quotes. Not a diagnosis and not financial advice. PulsCar is not affiliated with NHTSA. Check this car at your own mileage.